Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC JPS016 (TFA) | 99.47% | C50H64F3N7O10S | 25 MG
JPS016 (TFA) | 99.47% | C50H64F3N7O10S | 25 MG
Medchemexpress LLC SIYNFEKL TFA | 99.9% | 1013.14 (free acid) | 5 MG
SIYNFEKL TFA is an antigenic peptide, a variant of the major MHC class I-restricted epitope SIINFEKL. It stimulates specific T cells in experimental settings to study competitive interactions between T cells.
- Stimulates specific T cells
- Used to study competitive interaction between T cells
- Exhibits low affinity for OT-I T cell receptor (TCR)
- Applicable for detection of CD8+ T cells
Medchemexpress LLC 2-Furancarboxamide, 5-nitro-N-[4-[7-(1,2,3,6-tetrahydro-4-pyridinyl)imidazo[1,2-a]pyridin-3-yl]phenyl] | 25 MG
W1131 TFA is a potent STAT3 inhibitor that induces ferroptosis. It inhibits cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer. It effectively alleviates cancer cell chemoresistance to 5-FU, and regulates the cell cycle, DNA damage response, oxidative phosphorylation, the IL6-JAK-STAT3 pathway, and the ferroptosis pathway.
- Potent STAT3 inhibitor
- Induces ferroptosis
- Inhibits cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer
- Alleviates cancer cell chemoresistance to 5-FU
- Regulates the cell cycle
- Regulates DNA damage response
- Regulates oxidative phosphorylation
- Regulates the IL6-JAK-STAT3 pathway
- Regulates the ferroptosis pathway
Medchemexpress LLC FStAx-35R TFA | 97.4% | 2885.36 (free base) | 1 MG
fStAx-35R TFA is a hydrocarbon-stapled peptide that inhibits the Wnt/β-catenin signaling pathway by disrupting the β-catenin-TCF interaction. It can be utilized in cancer research.
- Inhibits Wnt/β-catenin signaling pathway
- Disrupts β-catenin-TCF interaction
- Suitable for cancer research
Medchemexpress LLC KRpep-2d TFA | 2098181-84-9 | 95.09% | 2675.03 | 25 MG
KRpep-2d TFA is a potent K-Ras inhibitor that inhibits the proliferation of K-Ras-driven cancer cells. It possesses a cyclic structure, with specific amino acid residues (Leu77, Ile9, and Asp12) being critical for its K-Ras inhibitory activity. This peptide can be used for cancer research.
- Potent K-Ras inhibitor
- Inhibits proliferation of K-Ras-driven cancer cells
- Cyclic structure important for inhibitory activity
- Demonstrates inhibitory activity in A427 cells
- Targets Ras
- Involved in GPCR/G Protein and MAPK/ERK Pathway
Medchemexpress LLC Gln-AMS (TFA) | 99.9% | 588.47 | 25 MG
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor that inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM. It is provided as a solid, white to off-white in appearance, and is stable under recommended storage conditions, making it suitable for laboratory research in metabolic enzyme, protease, anti-infection, and bacterial studies.
- Inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM.
- Available in various quantities for research needs.
- Stable under recommended storage conditions.
- Suitable for in vitro and in vivo dissolution protocols.